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Kirk Durston's Paper

PostPosted: Thu Apr 18, 2019 12:00 am
by stcordova

Re: Kirk Durston's Paper

PostPosted: Thu Apr 18, 2019 12:00 am
by stcordova
Accurate determination of protein structure by NMR spectroscopy is challenging for larger proteins, for which experimental data are often incomplete and ambiguous. Evolutionary sequence information together with advances in maximum entropy statistical methods provide a rich complementary source of structural constraints. We have developed a hybrid approach (evolutionary coupling–NMR spectroscopy; EC-NMR) combining sparse NMR data with evolutionary residue-residue couplings and demonstrate accurate structure determination for several proteins 6−41 kDa in size.